How Long Does Glutathione Last? Half-Life & Dosing Frequency
Glutathione has a reported half-life of ~10 minutes (IV). This page explains what that means for how long Glutathione stays active, how quickly it clears the body, and how often it is dosed in research.
What Is Glutathione's Half-Life?
The half-life of a compound is the time it takes for the amount in the body to fall to half its original level. For Glutathione, research reports a half-life of ~10 minutes (IV). The master antioxidant, crucial for detoxification and cellular protection.
How Long Does Glutathione Stay in Your System?
A compound is generally considered mostly cleared after about five half-lives. With a half-life of ~10 minutes (IV), Glutathione is largely cleared after roughly 50 minutes. Individual metabolism, dose, and dosing frequency can shift this estimate.
What This Means for Dosing Frequency
Research protocols commonly use Glutathione 1-2x daily (Morning on empty stomach). Dosing frequency is generally matched to the half-life and to how long the compound's effects last — peptides with shorter half-lives are often dosed more frequently, while longer-acting compounds may be dosed less often.
Frequently Asked Questions
What is Glutathione's half-life?
In the research literature, Glutathione is reported to have a half-life of ~10 minutes (IV). Half-life is the time it takes for the amount of a compound in the body to fall to half of its original level.
How long does Glutathione stay in your system?
As a general pharmacokinetic rule, a compound is mostly cleared after about five half-lives. For Glutathione, with a half-life of ~10 minutes (IV), that works out to roughly 50 minutes. Individual metabolism, dose, and dosing frequency can shift this.
How often is Glutathione dosed?
Research protocols commonly use Glutathione 1-2x daily. Dosing frequency is generally matched to the compound's half-life and to how long its effects last.