How Long Does NAD+ Last? Half-Life & Dosing Frequency
NAD+ has a reported half-life of 30-60 minutes (IV). This page explains what that means for how long NAD+ stays active, how quickly it clears the body, and how often it is dosed in research.
What Is NAD+'s Half-Life?
The half-life of a compound is the time it takes for the amount in the body to fall to half its original level. For NAD+, research reports a half-life of 30-60 minutes (IV). A coenzyme essential for cellular energy, DNA repair, and longevity pathways.
How Long Does NAD+ Stay in Your System?
A compound is generally considered mostly cleared after about five half-lives. With a half-life of 30-60 minutes (IV), NAD+ is largely cleared after roughly 300 minutes. Individual metabolism, dose, and dosing frequency can shift this estimate.
What This Means for Dosing Frequency
Research protocols commonly use NAD+ 1-2x per week (IV/IM) or daily (sublingual) (Morning). Dosing frequency is generally matched to the half-life and to how long the compound's effects last — peptides with shorter half-lives are often dosed more frequently, while longer-acting compounds may be dosed less often.
Frequently Asked Questions
What is NAD+'s half-life?
In the research literature, NAD+ is reported to have a half-life of 30-60 minutes (IV). Half-life is the time it takes for the amount of a compound in the body to fall to half of its original level.
How long does NAD+ stay in your system?
As a general pharmacokinetic rule, a compound is mostly cleared after about five half-lives. For NAD+, with a half-life of 30-60 minutes (IV), that works out to roughly 300 minutes. Individual metabolism, dose, and dosing frequency can shift this.
How often is NAD+ dosed?
Research protocols commonly use NAD+ 1-2x per week (iv/im) or daily (sublingual). Dosing frequency is generally matched to the compound's half-life and to how long its effects last.