KPV - Dosing Calculator & Information
Category: Anti-Inflammatory
A tripeptide derived from alpha-MSH with potent anti-inflammatory effects, especially for gut health.
Dosing Information
- Typical Dose Range: 200 - 500 mcg
- Common Vial Sizes: 5mg, 10mg
- Frequency: 1-2x daily
- Timing: Any time of day
Storage Guidelines
Before mixing: Room temperature up to 3 months, refrigerated (2-8°C) up to 2 years. Keep away from light. After mixing: Refrigerate at 2-8°C. Use within 3-4 weeks. Do not freeze.
Frequently Asked Questions
Can KPV help with gut issues?
Yes, KPV is primarily researched for inflammatory bowel conditions. It can be taken orally (reaches the gut directly) or injected subcutaneously for systemic effects.
Does KPV cause tanning like Melanotan?
No. Unlike Melanotan (which uses the full α-MSH structure), KPV uses only a small fragment that retains anti-inflammatory properties without melanotropic (tanning) effects.
How should I take KPV?
For gut issues, oral administration is popular (capsules or direct powder). For systemic inflammation or skin conditions, subcutaneous injection is common. Some use it topically for skin issues.
Can I combine KPV with BPC-157?
Yes, KPV and BPC-157 are commonly stacked for comprehensive gut healing. They work through different mechanisms and may be synergistic for IBD and leaky gut.
Research Summary
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-melanocyte-stimulating hormone (α-MSH). Research has demonstrated significant anti-inflammatory properties through inhibition of NF-κB and suppression of pro-inflammatory cytokines. It's particularly studied for inflammatory bowel diseases like Crohn's and ulcerative colitis, showing promise in reducing intestinal inflammation. KPV also has antimicrobial properties and promotes wound healing. Unlike full-length α-MSH, KPV doesn't cause skin darkening.
Related Peptides
- BPC-157 — A pentadecapeptide derived from human gastric juice, known for tissue healing properties.
- Larazotide — A peptide that regulates intestinal tight junctions, researched for celiac and leaky gut.
- LL-37 — A human host defense peptide with antimicrobial and wound healing properties.
Calculate Your KPV Dose
Use our free peptide calculator to get precise reconstitution volumes and injection dosages for KPV.