What Is Ipamorelin?
Category: Peptide
A selective growth hormone secretagogue (GHRP) known for being the 'cleanest' GH peptide with no significant effects on cortisol, prolactin, or appetite.
Detailed Explanation
Ipamorelin is a synthetic pentapeptide that selectively stimulates growth hormone release from the pituitary gland. What distinguishes Ipamorelin from other GHRPs is its exceptional selectivity - it promotes GH release without significantly increasing cortisol, prolactin, or appetite, earning it the reputation as the 'cleanest' growth hormone releasing peptide. It produces a controlled, dose-dependent GH pulse that mimics natural secretion patterns.
Practical Context
Ipamorelin is typically dosed at 100-300mcg, 2-3 times daily, on an empty stomach (2+ hours fasted). The most popular protocol is morning fasted, post-workout, and before bed. It is almost always combined with CJC-1295 no DAC (Mod GRF 1-29) for the synergistic GHRP + GHRH combination. Effects on sleep quality are often noticed within the first 1-2 weeks, while body composition changes typically become apparent after 4-6 weeks.
Frequently Asked Questions
Why is Ipamorelin considered the cleanest GHRP?
Unlike GHRP-2 and GHRP-6, Ipamorelin selectively targets GH release without significantly affecting cortisol, prolactin, or ghrelin (appetite). This provides GH benefits with minimal side effects.
Related Peptides
- Ipamorelin - A selective GH secretagogue with minimal effect on cortisol or prolactin. (Dosage | Calculator)
- CJC-1295 (no DAC) - A GHRH analog that stimulates growth hormone release without the Drug Affinity Complex. (Dosage | Calculator)
- GHRP-2 - A synthetic GHRP that stimulates GH release with less appetite stimulation than GHRP-6. (Dosage | Calculator)
- GHRP-6 - A hexapeptide that stimulates growth hormone release and increases appetite. (Dosage | Calculator)
- Sermorelin - A GHRH analog that naturally stimulates the pituitary to release growth hormone. (Dosage | Calculator)
Related Terms
- GHRP (Growth Hormone Releasing Peptide) - A category of peptides that trigger growth hormone release from the pituitary gland. Examples include Ipamorelin, GHRP-2, and GHRP-6.
- Secretagogue - A substance that promotes the secretion of a hormone. GH secretagogues stimulate the pituitary gland to release growth hormone naturally, unlike exogenous HGH which directly introduces the hormone.
- Cortisol - A stress hormone produced by the adrenal glands. Some GH peptides like GHRP-2 and GHRP-6 can slightly elevate cortisol levels, while ipamorelin does not.
- CJC-1295 - A synthetic analog of growth hormone releasing hormone (GHRH). Available in two forms: with DAC (long-acting, dosed weekly) and without DAC/Mod GRF 1-29 (short-acting, dosed 2-3x daily).