What Is MOTS-c?
Category: Peptide
Mitochondrial-derived peptide that regulates metabolic homeostasis, insulin sensitivity, and exercise capacity. Notable for its shorter shelf life after reconstitution (7-10 days).
Detailed Explanation
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome. It is a 16-amino acid peptide that plays a role in metabolic regulation, insulin sensitivity, and exercise physiology. MOTS-c is unique among peptides in that it is encoded by mitochondrial DNA rather than nuclear DNA, making it part of an emerging class of mitochondrial-derived bioactive molecules.
Practical Context
MOTS-c requires special attention to storage due to its shorter post-reconstitution shelf life of only 7-10 days (compared to 3-4 weeks for most peptides). This means smaller reconstitution volumes or more frequent reconstitution may be necessary to avoid waste. It is typically dosed at 5-10mg per week, administered subcutaneously. MOTS-c is popular among researchers interested in metabolic health, exercise performance, and longevity.
Frequently Asked Questions
Why does MOTS-c have a shorter shelf life?
MOTS-c is less stable in solution than many other peptides, leading to faster degradation. Reconstitute only what you can use within 7-10 days and keep strictly refrigerated.
Related Peptides
- MOTS-c - A mitochondrial-derived peptide that regulates metabolic homeostasis and exercise mimetic. (Dosage | Calculator)
- Semaglutide - A GLP-1 receptor agonist used for weight management and blood sugar control. (Dosage | Calculator)
- Tirzepatide - A dual GIP and GLP-1 receptor agonist for weight management. (Dosage | Calculator)
Related Terms
- Reconstitution - The process of adding bacteriostatic water to lyophilized peptide powder to create an injectable solution. Always inject water slowly along the vial wall - never spray directly on the powder.
- Lyophilized (Freeze-Dried) - The powder form of peptides as they arrive from the manufacturer. Lyophilized peptides are stable for extended storage and must be reconstituted with bacteriostatic water before use.
- Half-Life - The time it takes for half of a substance to be eliminated from the body. Determines dosing frequency - shorter half-life peptides need more frequent dosing.