What Is Sermorelin?
Category: Peptide
One of the earliest GHRH analogs developed. Stimulates natural growth hormone production and is commonly prescribed by anti-aging clinics. Has a well-established safety record.
Detailed Explanation
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of the 44-amino acid human Growth Hormone Releasing Hormone (GHRH). It was one of the first GHRH analogs developed and has the longest clinical track record of any GH secretagogue. Sermorelin stimulates the pituitary gland to produce and release growth hormone naturally, making it a true secretagogue rather than a direct hormone replacement.
Practical Context
Sermorelin is typically dosed at 200-500mcg once daily, administered subcutaneously before bed on an empty stomach. It is commonly prescribed by anti-aging and wellness clinics due to its well-established safety profile. While it has a very short half-life (10-20 minutes), its effect on GH release lasts longer because it stimulates the pituitary to produce a GH pulse. It can be used alone or combined with a GHRP for enhanced effects.
Frequently Asked Questions
Is Sermorelin FDA approved?
Sermorelin was previously FDA-approved for diagnostic use and for treating growth hormone deficiency in children. While the original brand was discontinued, it remains available through compounding pharmacies.
Related Peptides
- Sermorelin - A GHRH analog that naturally stimulates the pituitary to release growth hormone. (Dosage | Calculator)
- CJC-1295 (no DAC) - A GHRH analog that stimulates growth hormone release without the Drug Affinity Complex. (Dosage | Calculator)
- Ipamorelin - A selective GH secretagogue with minimal effect on cortisol or prolactin. (Dosage | Calculator)
Related Terms
- GHRH (Growth Hormone Releasing Hormone) - A category of peptides that amplify growth hormone pulses. Examples include CJC-1295 and Sermorelin. Most effective when combined with a GHRP.
- Secretagogue - A substance that promotes the secretion of a hormone. GH secretagogues stimulate the pituitary gland to release growth hormone naturally, unlike exogenous HGH which directly introduces the hormone.
- GH (Growth Hormone) - A hormone produced by the pituitary gland that stimulates growth, cell reproduction, and regeneration. GH secretagogue peptides stimulate the body's natural GH production.