Semaglutide - Dosing Calculator & Information
Category: GLP-1 Agonist
A GLP-1 receptor agonist used for weight management and blood sugar control.
Dosing Information
- Typical Dose Range: 250 - 2500 mcg
- Common Vial Sizes: 3mg, 5mg, 10mg
- Frequency: 1x per week
- Timing: Same day each week, any time of day
Storage Guidelines
Before mixing: Refrigerate at 2-8°C for up to 2 years. Can store at room temperature (up to 30°C) for 28 days if needed. After mixing: Refrigerate at 2-8°C. Use within 8 weeks. Highly stable after reconstitution.
Frequently Asked Questions
How much weight can I lose on semaglutide?
Clinical trials show average weight loss of 15-17% of body weight over 68 weeks at full dose. Individual results vary based on diet, exercise, and starting weight. Some lose more, some less.
Why do I need to titrate up slowly?
Slow titration (starting at 0.25mg and increasing monthly) helps your body adjust and minimizes side effects like nausea, vomiting, and diarrhea. Rushing the dose often leads to severe GI symptoms.
What are common semaglutide side effects?
The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation, and stomach pain. These usually improve over time. More serious but rare effects include pancreatitis and gallbladder issues.
Semaglutide vs Tirzepatide - which is better?
Tirzepatide (Mounjaro/Zepbound) has shown slightly better weight loss results in trials (up to 22% vs 17%). However, semaglutide has more long-term safety data. Both are effective - choice often depends on availability and cost.
Research Summary
Semaglutide is an FDA-approved GLP-1 receptor agonist originally developed for Type 2 diabetes (Ozempic) and later approved for chronic weight management (Wegovy). It mimics the hormone GLP-1, which regulates appetite, food intake, and blood sugar levels. Clinical trials have demonstrated impressive weight loss results, with participants losing an average of 15-17% of body weight over 68 weeks. Semaglutide works by slowing gastric emptying, reducing appetite, and improving insulin sensitivity. It also shows cardiovascular benefits, reducing major adverse cardiac events in at-risk patients. The once-weekly dosing makes it convenient compared to daily alternatives.
Related Peptides
- Tirzepatide — A dual GIP and GLP-1 receptor agonist for weight management.
- AOD-9604 — A modified fragment of human growth hormone targeting fat metabolism.
- MOTS-c — A mitochondrial-derived peptide that regulates metabolic homeostasis and exercise mimetic.
Calculate Your Semaglutide Dose
Use our free peptide calculator to get precise reconstitution volumes and injection dosages for Semaglutide.