Tirzepatide - Dosing Calculator & Information
Category: GLP-1/GIP Agonist
A dual GIP and GLP-1 receptor agonist for weight management.
Dosing Information
- Typical Dose Range: 2500 - 15000 mcg
- Common Vial Sizes: 5mg, 10mg, 15mg, 30mg
- Frequency: 1x per week
- Timing: Same day each week, any time of day
Storage Guidelines
Before mixing: Refrigerate at 2-8°C for up to 2 years. Can store at room temperature (up to 30°C) for 21 days if needed. After mixing: Refrigerate at 2-8°C. Use within 6 weeks. Very stable peptide after mixing.
Frequently Asked Questions
Is tirzepatide more effective than semaglutide?
Head-to-head trials show tirzepatide produces greater weight loss (up to 22% vs 17%) and better blood sugar control. The dual GIP/GLP-1 mechanism appears more effective than GLP-1 alone.
What is the tirzepatide dosing schedule?
Start at 2.5mg weekly for 4 weeks, then increase to 5mg. Continue increasing by 2.5mg every 4 weeks as tolerated, up to a maximum of 15mg weekly.
Can tirzepatide cause muscle loss?
Like all rapid weight loss methods, some muscle loss can occur. Adequate protein intake (0.7-1g per pound of body weight) and resistance training help preserve muscle mass while on tirzepatide.
How long do tirzepatide side effects last?
GI side effects (nausea, diarrhea) are usually worst during dose increases and typically improve within 2-4 weeks. Eating smaller meals and avoiding fatty foods helps manage symptoms.
Research Summary
Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist FDA-approved for Type 2 diabetes (Mounjaro) and weight management (Zepbound). Unlike semaglutide which only targets GLP-1, tirzepatide activates both GIP and GLP-1 receptors, providing enhanced metabolic benefits. Clinical trials (SURMOUNT) showed unprecedented weight loss results, with participants losing up to 22.5% of body weight - more than any other approved medication. It improves insulin sensitivity, reduces appetite, and may have additional benefits for fatty liver disease. The dual mechanism appears to provide superior efficacy compared to GLP-1 agonists alone.
Related Peptides
- Semaglutide — A GLP-1 receptor agonist used for weight management and blood sugar control.
- AOD-9604 — A modified fragment of human growth hormone targeting fat metabolism.
- MOTS-c — A mitochondrial-derived peptide that regulates metabolic homeostasis and exercise mimetic.
Calculate Your Tirzepatide Dose
Use our free peptide calculator to get precise reconstitution volumes and injection dosages for Tirzepatide.